Реакция #1174

Уравнение реакции

K2CO3

1-Benzyloxycarbonyl-4-phthalimidylpiperidine

hydrazine monohydrate

→

4-amino-1-benzyloxycarbonylpiperidine

Выход 85.0%

Растворители

ethanol

Brine

Условия реакции

Обработка

1. 1
   Экстракцияthe mixture was extracted with 5% MeOH/CHCl3 (3×)
2. 2
   ПромывкаThe combined extracts were washed with 2N aq. HCl, 2N aq. NaOH, brine solution
3. 3
   Сушкаdried over Na2SO4
4. 4
   Концентрированиеconcentrated

Методика

1-Benzyloxycarbonyl-4-phthalimidylpiperidine (1.50 g, 4.27 mmol), prepared in Example 16B, was taken up in 20 mL of ethanol. To this solution was added hydrazine monohydrate (35 mL, 700 mmol) and this mixture was heated at 100° C. for 3 h. Brine solution (40 mL) and 10% aq. K2CO3 (60 mL) were added and the mixture was extracted with 5% MeOH/CHCl3 (3×). The combined extracts were washed with 2N aq. HCl, 2N aq. NaOH, brine solution, dried over Na2SO4 and concentrated to give 0.847 g, (85%) of 4-amino-1-benzyloxycarbonylpiperidine. [1H]-NMR(CDCl3) consistent with structure.

Источник