Реакция #1172

Уравнение реакции

4-Hydroxypiperidine

Et3N

benzyl chloroformate

CHCl3 MeOH

→

N-Cbz-piperidine

Выход 59.2%

Растворители

CH2Cl2

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas added

Методика

4-Hydroxypiperidine (10.8 g, 107 mmol) and Et3N (17 mL, 123 mmol) in 80 mL of CH2Cl2 was cooled in an ice bath whereupon benzyl chloroformate (16.3 mL, 114 mmol) was added. After stirring 1.5 h at R.T. the mixture was subjected to standard work-up conditions to give 13.9 g (55%) of N-Cbz-piperidine after chromatography (CHCl3 /MeOH; 10:1). [1H]-NMR(CDCl3) consistent with structure.

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