Реакция #1171

Уравнение реакции

4-Piperidinecarboxamide

benzyl bromide

→

N-benzyl-4-piperidinecarboxamide

Выход 35.0%

Растворители

EtOAc

DMSO

Условия реакции

Обработка

1. 1
   Промывкаwashed with 1N aq. HCl, 5N aq. NaOH
2. 2
   Сушкаdried over MgSO4
3. 3
   Концентрированиеconcentrated

Методика

4-Piperidinecarboxamide (10.2 g, 78.0 mmol) in DMSO (10 mL) was treated with benzyl bromide (20.0 mL, 168 mmol). The mixture was diluted with EtOAc and washed with 1N aq. HCl, 5N aq. NaOH, dried over MgSO4, and concentrated to give 5.90 g (35%) of N-benzyl-4-piperidinecarboxamide. [1H]-NMR(CDCl3) consistent with structure.

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