Реакция #11676

Уравнение реакции

(R)-1-carbomethoxymethyl-3-(5-chloroindole-2-carbonylamino)-3,4-dihydrocarbostyril

Lithium hydroxide monohydrate

hydrochloric acid

→

title compound

Выход 95.6%

(R)-1-carboxymethyl-3-(5-chloroindole-2-carbonylamino)-3,4-dihydrocarbostyril

Выход 95.6%

Растворители

tetrahydrofuran

methanol

water

Условия реакции

Обработка

1. 1
   Экстракцияwas followed by extraction with ethyl acetate (20 mL twice)
2. 2
   ПромывкаThe combined organic layers were washed with brine (10 mL)
3. 3
   Сушкаdried over anhydrous sodium sulfate
4. 4
   Другоеevaporated under vacuum

Методика

(R)-1-carbomethoxymethyl-3-(5-chloroindole-2-carbonylamino)-3,4-dihydrocarbostyril (Example 7) (13 mg) was dissolved in a 2:2:1 mixture of tetrahydrofuran, methanol, and water (5 mL). Lithium hydroxide monohydrate (3 mg) was added, and the resulting mixture was stirred at room temperature for 2 h. Addition of 1.0 M aqueous hydrochloric acid (10 mL) was followed by extraction with ethyl acetate (20 mL twice). The combined organic layers were washed with brine (10 mL), dried over anhydrous sodium sulfate, and evaporated under vacuum to provide the title compound (12 mg). HPLC/MS [M+H]+, 398.

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