Реакция #1163967

Уравнение реакции

N-3,3-Diphenylpropylpiperazine

2,3,4-trimethoxybenzyl chloride

tributylamine

→

1-(3,3-diphenylpropyl)-4-(2,3,4-trimethoxybenzyl)piperazine

Выход 91.2%

Растворители

ethylene glycol diethyl ether

Условия реакции

Обработка

1. 1
   Температураthe resulting solution was heated at the refluxing temperature for 2.5 hours
2. 2
   ДругоеThe reaction liquid
3. 3
   workup.WAITwas left
4. 4
   Температураto cool
5. 5
   Фильтрацияfiltered

Методика

N-3,3-Diphenylpropylpiperazine in the amount of 1.4 g (0.005 mole), 1.1 g (0.005 mole) of 2,3,4-trimethoxybenzyl chloride, and 0.93 g (0.005 mole) of tributylamine were dissolved in 10 ml of ethylene glycol diethyl ether, and the resulting solution was heated at the refluxing temperature for 2.5 hours. The reaction liquid was left to cool, and filtered, and concentration of the filtrate under reduced pressure produced 2.1 g of oily 1-(3,3-diphenylpropyl)-4-(2,3,4-trimethoxybenzyl)piperazine (91.2% yield).

Источник