Реакция #1161

ord-6d44d87ee23a4984ad13cff1877a23a4

Уравнение реакции

CC(=O)O
acetic acid
[K+].[O]=[Mn](=[O])(=[O])[O-]
KMnO4
CSc1ccc(C(C)=O)cc1
4-(methylthio)acetophenone
O=S([O-])[O-].[Na+].[Na+]
sodium sulfite
→
CC(=O)c1ccc(S(C)(=O)=O)cc1
4-(methylsulfonyl)acetophenone

Реактанты

CC(=O)O
acetic acid
[K+].[O]=[Mn](=[O])(=[O])[O-]
KMnO4
CSc1ccc(C(C)=O)cc1
4-(methylthio)acetophenone
O=S([O-])[O-].[Na+].[Na+]
sodium sulfite

Реагенты

Нет

Растворители

O
water
O
water

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Обработка

  1. 1
    Другоеto return to room temperature
  2. 2
    workup.WAITThis is left
  3. 3
    ДругоеThe solid obtained
  4. 4
    Фильтрацияis filtered off
  5. 5
    Промывкаwashed copiously with water
  6. 6
    Другоеrecrystallized from 95% ethanol

Методика

A solution of 152 g (0.96 mol) of KMnO4 in 3.5 1 of water is introduced into a mixture of 117.1 g (0.7 mol) of 4-(methylthio)acetophenone, prepared in Example 2c, and 292 ml of acetic acid. 2.3 l of water are added and the reaction temperature is allowed to return to room temperature. Saturated sodium sulfite solution is added dropwise until the solution is decolorized. This is left to stand overnight at room temperature. The solid obtained is filtered off, washed copiously with water and recrystallized from 95% ethanol to give 91.5 g of 4-(methylsulfonyl)acetophenone.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US05723485uspto-grants-1998_03