Реакция #1159046

Уравнение реакции

2-imino-3-benzoyl-7-dimethylamino 4-(3-methoxy-4,5-methylenedioxyphenyl)-chromane

triethylamine

→

title compound

Выход 72.0%

2-Amino-3-benzoyl-7-dimethylamino-4-(3-methoxy-4,5-methylenedioxyphenyl)-4H-chromene

Выход 72.0%

Растворители

ethanol

Условия реакции

Обработка

1. 1
   КонцентрированиеIt was concentrated
2. 2
   Другоеthe residue was purified by column chromatography (silica gel, EtOAc/Hexane=1:5)

Методика

A solution of 2-imino-3-benzoyl-7-dimethylamino 4-(3-methoxy-4,5-methylenedioxyphenyl)-chromane (26 mg, 0.059 mmol) and triethylamine (0.1 ml) in ethanol (5 ml) was refluxed for 12 h. It was concentrated, and the residue was purified by column chromatography (silica gel, EtOAc/Hexane=1:5) to give 18 mg (72%) of the title compound. 1H NMR (CDCl3): 7.40-7.30 (m, 2H), 7.18-7.14 (m, 2H), 6.86 (d, 1H), 6.50-6.34 (m, 2H), 6.00 (d, 1H), 5.85-5.81 (m, 2H), 5.73 (d, 1H), 4.73 (s, 1H), 3.67 (s, 3H), 2.91 (s, 6H).

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