Реакция #11523

Уравнение реакции

water

4-(2-Chloroethyl)morpholine hydrochloride

1-benzothiophene-4-ol

potassium carbonate

dimethylformamide

→

product

2-[(1-Benzothien-4-yloxy)ethyl]morpholine

Условия реакции

Обработка

1. 1
   ТемператураAfter cooling
2. 2
   Экстракцияextracted twice with ethyl acetate
3. 3
   ПромывкаThe combined solvent phase was washed twice with brine
4. 4
   Сушкаdried (magnesium sulphate)
5. 5
   Другоеevaporated

Методика

4-(2-Chloroethyl)morpholine hydrochloride (0.74 g), 1-benzothiophene-4-ol (0.5 g) and potassium carbonate (1.1 g) in dimethylformamide (15 ml) were heated and stirred at 80° C. for 6 h. After cooling, the mixture was poured into water and extracted twice with ethyl acetate. The combined solvent phase was washed twice with brine, dried (magnesium sulphate) and evaporated to give the product (0.7 g).

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