Реакция #1149061

Уравнение реакции

diisopropylamine

triethylamine

6-bromo-2-naphthoyl chloride

→

title compound

6-bromo-N,N-diisopropyl-2-naphthamide

Растворители

THF

THF

Условия реакции

Обработка

1. 1
   Температураcooling
2. 2
   ДругоеA half amount of the solvent was evaporated under reduced pressure
3. 3
   workup.ADDITIONthe residue was diluted with ethyl acetate
4. 4
   Промывкаwashed successively with water, 1N aqueous sodium hydroxide solution, water and saturated brine
5. 5
   Сушкаdried over magnesium sulfate
6. 6
   ДругоеThe solvent was evaporated
7. 7
   Промывкаthe obtained solid was washed with isopropyl ether

Методика

To a solution (800 mL) of diisopropylamine (112 mL) and triethylamine (112 mL) in THF was added dropwise a solution (400 mL) of 6-bromo-2-naphthoyl chloride in THF under ice-cooling. The mixture was stirred at room temperature for 1 hr. A half amount of the solvent was evaporated under reduced pressure, and the residue was diluted with ethyl acetate, washed successively with water, 1N aqueous sodium hydroxide solution, water and saturated brine and dried over magnesium sulfate. The solvent was evaporated and the obtained solid was washed with isopropyl ether to give the title compound (117 g) as colorless flakes.

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