Реакция #1144440

Уравнение реакции

acetone

2,4,6-trichloro-1,3,5-triazine

NaOH

tert-butylamine

→

2-tert-butylamino-4,6-dichloro-1,3,5-triazine

Выход 97.6%

Растворители

water

Условия реакции

Обработка

1. 1
   workup.ADDITIONare added, under nitrogen stream
2. 2
   Другоеat about 0° C
3. 3
   Другоеfor 30 minutes
4. 4
   ФильтрацияAfter filtration
5. 5
   Промывкаwashing with water to neutral pH
6. 6
   Другоеthe resulting precipitate is dried

Методика

—400 ml of acetone cooled to 0° C. are added, under nitrogen stream, with 92.3 g of 2,4,6-trichloro-1,3,5-triazine, then with 38 g of tert-butylamine, always keeping the temperature at about 0° C. After keeping the resulting mixture at this temperature for 30 minutes, 66.7 g of a 30% NaOH aqueous solution, then 400 ml of water are dropped therein, and the resulting mixture is stirred for 1 hour at 0° C. After filtration and washing with water to neutral pH, the resulting precipitate is dried to obtain 108 g of 2-tert-butylamino-4,6-dichloro-1,3,5-triazine. M.p. 129-30° C.

Источник