Реакция #1144435

Уравнение реакции

5-ethyluracil

potassium carbonate

→

1-butyl-5-ethyluracil

Выход 69.0%

Растворители

dimethylformamide

Условия реакции

Обработка

1. 1
   КонцентрированиеThe reaction mixture was concentrated under reduced pressure
2. 2
   Концентрированиеthe organic layer was concentrated under reduced pressure
3. 3
   Промывкаeluted with 30% ethyl acetate/hexane

Методика

To a solution of 5.6 g (40 mmol) of 5-ethyluracil in 60 ml of dimethylformamide, 5.5 g (40 mmol) of potassium carbonate and 2.3 ml (20 mmol) of n-iodobutane were added and stirred for 2 hours at 120° C. The reaction mixture was concentrated under reduced pressure and distributed between dichloromethane and aqueous solution of ammonium chloride, and the organic layer was concentrated under reduced pressure. The residue was adsorbed on a silica gel column and eluted with 30% ethyl acetate/hexane to obtain 2.7 g of 1-butyl-5-ethyluracil (Yield: 69%).

Источник