Реакция #1135839

Уравнение реакции

N-cyclopropyl-2-nitroaniline

ammonium formate

→

N1-cyclopropylbenzene-1,2-diamine

Выход 97.4%

Растворители

methanol

Условия реакции

Обработка

1. 1
   ТемператураThe mixture was heated
2. 2
   Температураto reflux under a nitrogen atmosphere overnight
3. 3
   Фильтрацияfiltered
4. 4
   КонцентрированиеThe filtrate was concentrated
5. 5
   Другоеpurified by biotage column chromatography

Методика

To a solution of N-cyclopropyl-2-nitroaniline (365 mg, 2.05 mmol) and ammonium formate (516 mg, 8.2 mmol) in methanol was added catalytic amount of palladium on carbon (5%). The mixture was heated to reflux under a nitrogen atmosphere overnight and filtered. The filtrate was concentrated and purified by biotage column chromatography to give N1-cyclopropylbenzene-1,2-diamine (296 mg)

Источник