Реакция #11264

Уравнение реакции

phosphorus oxychloride

ethylacetoacetate

cyanoacetamide

→

3-cyano-2,5-dihydroxy-4-methylpyridine

Условия реакции

Методика

Amine was generated by the condensation of ethylacetoacetate with cyanoacetamide followed by reaction with phosphorus oxychloride to provide 3-cyano-2,5-dihydroxy-4-methylpyridine. Hydrogenation with palladium dichloride gave the 3-cyano-4-methylpyridine which was hydrogenated with Raney nickel in ammonia and ethanol to afford the desired amine (J. Org. Chem. 1959, 25, 560.).

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