Реакция #1121743

Уравнение реакции

Boc-threonine

glycine ethyl ester hydrochloride

triethylamine

N,N′-dicyclohexylcarbodiimide

hydroxybenzotriazole

→

Boc-Thr-Gly-OEt

Выход 85.4%

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   Другоеthe mixture was reacted at room temperature for overnight
2. 2
   ДругоеAfter completion of the reaction, reaction mixture
3. 3
   Фильтрацияwas filtered
4. 4
   Экстракцияthe filtrate was extracted with ethyl acetate
5. 5
   КонцентрированиеThe extract was concentrated under reduced pressure
6. 6
   Другоеthe product was crystallized from hexane

Методика

Boc-threonine (produced by Wako Pure Chemical Industries Ltd.) (11.0 g, 50 mmol) and glycine ethyl ester hydrochloride (produced by Wako Pure Chemical Industries Ltd.) (8.4 g, 60 mmol) were dissolved in dichloromethane (250 mL). After triethylamine (8.4 mL, 60 mmol), N,N′-dicyclohexylcarbodiimide (DCC, 12.4 g, 60 mmol) and hydroxybenzotriazole (9.2 g, 60 mmol) were further added thereto, the mixture was reacted at room temperature for overnight with stirring. After completion of the reaction, reaction mixture was filtered, and then the filtrate was extracted with ethyl acetate. The extract was concentrated under reduced pressure, and the product was crystallized from hexane, to obtain Boc-Thr-Gly-OEt (1) (13.0 g) (yield; 85.1%).

Источник