Реакция #1121724

Уравнение реакции

ethyl 4-bromobutanoate

1-methylpiperazine

K2CO3

→

ethyl 4-(4-methylpiperzin-1-yl)butanoate

Выход 96.0%

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   Температураwas refluxed for 18 h
2. 2
   Концентрированиеbefore concentrated in vacuo
3. 3
   ДругоеThe organic layer was then separated
4. 4
   Экстракцияthe aqueous layer was extracted with dichloromethane (DCM, 3×150 mL)
5. 5
   ПромывкаThe combined organic extracts were washed with water (150 mL)
6. 6
   Сушкаdried (Na2SO4)
7. 7
   Концентрированиеconcentrated in vacuo

Методика

A mixture of ethyl 4-bromobutanoate (5.75 g, 29.5 mmol; Aldrich No. 167118) and 1-methylpiperazine (3.55 mL, 32.0 mmol; Aldrich No. 130001) and anhydrous K2CO3 (4.5 g, 32.5 mmol; Fisher No. P208) in acetonitrile (MeCN, 150 mL) was refluxed for 18 h before concentrated in vacuo. The organic layer was then separated and the aqueous layer was extracted with dichloromethane (DCM, 3×150 mL). The combined organic extracts were washed with water (150 mL), dried (Na2SO4), and concentrated in vacuo to give ethyl 4-(4-methylpiperzin-1-yl)butanoate (6.01 g, 96%) as a yellow oil.

Источник