Реакция #1121716

Уравнение реакции

hydroquinone

1,6-dibromo hexane

Potassium hydroxide

→

4-(6-bromohexyloxy)phenol

Выход 39.4%

Растворители

methanol

Условия реакции

Обработка

1. 1
   Другоеfluxed at 60° C.
2. 2
   Другое(Celsius) overnight
3. 3
   Другоеis lowered to a room temperature
4. 4
   Другоеmethanol was evaporated from the reaction mixture
5. 5
   ЭкстракцияThen, the reaction mixture was extracted three times with water (100 ml (milliliters)) and ethyl acetate (100 ml (milliliters))
6. 6
   ДругоеWater was removed over magnesium sulfate
7. 7
   Другоеthe solvents were evaporated
8. 8
   Другоеthe resulting reaction mixture
9. 9
   Другоеwas purified

Методика

As shown in the following Scheme, hydroquinone (1) (4.5 g (grams)) and 1,6-dibromo hexane (2) (10 g (grams)) were dissolved in methanol (100 ml (milliliters)) at a room temperature. Potassium hydroxide (2.3 g (grams)) was added to the resulting mixture solution, and then fluxed at 60° C. (Celsius) overnight. Next day, the temperature of the reaction mixture is lowered to a room temperature, and methanol was evaporated from the reaction mixture. Then, the reaction mixture was extracted three times with water (100 ml (milliliters)) and ethyl acetate (100 ml (milliliters)). Water was removed over magnesium sulfate, and the solvents were evaporated, and the resulting reaction mixture was purified using a column chromatography (developer solution: ethylacetate/hexane=1/5 volume ratio) to obtain 4.4 g (grams) of 4-(6-bromohexyloxy)phenol (3).

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