Реакция #1120230

Уравнение реакции

5-acetylaminomethyl-2-chloroacetylfuran

diaminomethylenethiourea

→

4-(5-acetylaminomethylfuran-2-yl)-2-(diaminomethyleneamino)thiazole

Выход 46.6%

Растворители

ethanol

Условия реакции

Обработка

1. 1
   ДругоеThe solvent was evaporated in vacuo
2. 2
   workup.DISSOLUTIONthe residue was dissolved in water (300 ml)
3. 3
   ФильтрацияThe resulting precipitate was collected by filtration
4. 4
   Промывкаwashed with water
5. 5
   Другоеrecrystallized from a mixture of methanol, tetrahydrofuran and diisopropyl ether

Методика

A solution of 5-acetylaminomethyl-2-chloroacetylfuran (39.9 g) and diaminomethylenethiourea (21.9 g) in ethanol (400 ml) was refluxed for two hours with stirring. The solvent was evaporated in vacuo and the residue was dissolved in water (300 ml). The solution was basified with an aqueous potassium carbonate. The resulting precipitate was collected by filtration, washed with water and recrystallized from a mixture of methanol, tetrahydrofuran and diisopropyl ether to afford 4-(5-acetylaminomethylfuran-2-yl)-2-(diaminomethyleneamino)thiazole (24.1 g).

Источник