Реакция #1118699

Уравнение реакции

H2O

cyanogen bromide

3-(4-methyl-1-piperazinyl)-5-methoxy-1-phenylsulfonyl-1H-indazole

potassium carbonate

→

4-(5-methoxy-1-phenylsulfonyl-1H-indazol-3-yl)-1-piperazinecarbonitrile

Выход 50.0%

Растворители

DMSO

dimethylsulfoxide

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas added dropwise
2. 2
   ДругоеThe solid which formed
3. 3
   Другоеwas collected
4. 4
   Промывкаwashed well with H2O
5. 5
   ДругоеThe solid was dried
6. 6
   Другоеto yield 41.0 g
7. 7
   ДругоеA 5.0 sample was recrystallized twice from ethanol (utilizing decolorizing carbon)

Методика

To a stirred mixture of 3-(4-methyl-1-piperazinyl)-5-methoxy-1-phenylsulfonyl-1H-indazole (55.0 g, 0.14 mol) of Example 5d, potassium carbonate (22.0 g, 0.16 mol) and dimethylsulfoxide (DMSO) [500 ml] under N2 was added dropwise, cyanogen bromide (16.0 g, 0.15 mol) dissolved in DMSO (125 ml). The reaction was stirred at room temperature for 4 hours and was then poured into H2O (2.5 l). The solid which formed was collected and washed well with H2O. The solid was dried and weighed to yield 41.0 g. A 5.0 sample was recrystallized twice from ethanol (utilizing decolorizing carbon) to afford 3.5 g (50%) of 4-(5-methoxy-1-phenylsulfonyl-1H-indazol-3-yl)-1-piperazinecarbonitrile. m.p. 171°-173° C.

Источник