Реакция #1116307

Уравнение реакции

Compound 83

1-Chloro-5H-benzo[c][1,8]naphthyridin-6-one

X-Phos

KOH

3-chloro-4-(1-methyl-1H-imidazol-2-ylsulfanyl)-phenylamine

→

156

Выход 2.1%

1-[3-Chloro-4-(1-methyl-1H-imidazol-2-ylsulfanyl)-phenylamino]-5H-benzo[c][1,8]naphthyridin-6-one

Выход 2.1%

Растворители

tert-amyl alcohol

MeOH

Условия реакции

Обработка

1. 1
   Фильтрацияfiltered
2. 2
   Другоеpurified via prep-LC-MS

Методика

Compound 83 (100 mg, 0.43 mmol), 3-chloro-4-(1-methyl-1H-imidazol-2-ylsulfanyl)-phenylamine (156 mg, 0.65 mmol), Pd(OAc)2 (5 mg, 0.02 mmol), X-Phos (21 mg, 0.04 mmol), and KOH (97 mg, 1.73 mmol) were suspended in tert-amyl alcohol (2 mL), and stirred overnight at 100° C. The reaction mixture was diluted with MeOH, filtered, and purified via prep-LC-MS to provide 156 (4 mg, 2% yield) as a solid. LC-MS (M+H=434, obsd.=434).

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