Реакция #1106678

Уравнение реакции

((3,4-Dihydro-2H-benzo[b][1,4]dioxepin-3-yl)methyl)amine

sulfamide

Chloroform

→

title compound

((3,4-Dihydro-2H-benzo[b][1,4]dioxepin-3-yl)methyl)sulfamide

Растворители

dioxane

Условия реакции

Обработка

1. 1
   Температураheated
2. 2
   Температураto reflux overnight
3. 3
   Другоеthe precipitate was removed by filtration
4. 4
   КонцентрированиеThe filtrate was concentrated under vacuum
5. 5
   Другоеpurified by chromatography (2% to 8% acetone in dichloromethane)

Методика

((3,4-Dihydro-2H-benzo[b][1,4]dioxepin-3-yl)methyl)amine (2.90 g, 16.2 mmol) and sulfamide (3.11 g, 32.4 mmol) were combined in dry dioxane (60 ml) and heated to reflux overnight. Chloroform was added and the precipitate was removed by filtration. The filtrate was concentrated under vacuum and purified by chromatography (2% to 8% acetone in dichloromethane) to yield the title compound as an off-white solid.

Источник