Реакция #1106675

Уравнение реакции

3-bromo-5-tert-butylbenzaldehyde

malonic acid

ammonium acetate

→

product

Выход 51.6%

3-amino-3-(3-bromo-5-tert-butylphenyl)propionic acid

Выход 51.6%

Растворители

isopropanol

Условия реакции

Обработка

1. 1
   Температураwas heated
2. 2
   Температураat reflux under nitrogen for 3 h
3. 3
   Другоеto afford a thick colorless solid
4. 4
   ФильтрацияThe solid was filtered hot
5. 5
   Промывкаwashed with hot isopropanol (2×25 mL)
6. 6
   Другоеdried in vacuo

Методика

A suspension of 3-bromo-5-tert-butylbenzaldehyde (4.17 g, 17.30 mmol), malonic acid (2.15 g, 20.72 mmol) and ammonium acetate (2.66 g, 34.59 mmol) in isopropanol (35 mL) was heated at reflux under nitrogen for 3 h to afford a thick colorless solid. The solid was filtered hot, washed with hot isopropanol (2×25 mL) and dried in vacuo to give the desired racemic product as a colorless solid (2.68 g).

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