Реакция #1106668

Уравнение реакции

Compound 17

1-Chloro-5-(2-(dimethylamino)ethylamino)anthracene-9,10-dione

ethanolamine

→

Compound 21

Выход 38.8%

1-(2-(dimethylamino)ethylamino)-5-(2-hydroxyl ethylamino)anthracene-9,10-dione

Выход 38.8%

Растворители

CH2Cl2

Условия реакции

Обработка

1. 1
   ТемператураThe mixture was cooled to room temperature
2. 2
   Экстракцияextracted with water and brine
3. 3
   СушкаThe organic layer was dried (Na2SO4)
4. 4
   Другоеevaporated

Методика

A mixture of Compound 17 (0.87 g, 2.7 mmol) and ethanolamine (0.8 mL, 13.23 mmol) was heated in an oil bath (−150° C.) for 18 hours. The mixture was cooled to room temperature, dissolved in 100 mL CH2Cl2 and extracted with water and brine. The organic layer was dried (Na2SO4) and evaporated to provide Compound 21 (370 mg). This product was used in the next step without any purification. Rf (9:1 CHCl3/MeOH) 0.19. The structure of Compound 21 is given below:

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