Реакция #1106642

Уравнение реакции

NaOH

1-(2-hydroxy-4-(methoxymethoxy)phenyl)-3-(6-methoxypyridin-3-yl)propan-1-one

TFA

→

white solid

Выход 35.8%

2,4-dihydroxyphenyl-3-(6-methoxypyridin-3-yl)propan-1-one

Выход 35.8%

Растворители

CH3CN

Условия реакции

Обработка

1. 1
   ЭкстракцияThe aqueous was extracted with 100 ml EtOAc
2. 2
   ПромывкаThe organic layer was washed with brine
3. 3
   Сушкаdried (Na2SO4)
4. 4
   Концентрированиеconcentrated
5. 5
   ДругоеThe residue was purified by silica gel chromatography (15% EtOAc/Hexane)

Методика

To a solution of 1-(2-hydroxy-4-(methoxymethoxy)phenyl)-3-(6-methoxypyridin-3-yl)propan-1-one (1.62 g, 5.11 mmol) in CH3CN (30 ml) at room temperature was added TFA (2 ml) dropwise, two drops of water. The reaction was stirred at same temperature for 8 h. Aqueous 1N NaOH was added to the reaction mixture until pH=7. The aqueous was extracted with 100 ml EtOAc, and the organic layers were combined. The organic layer was washed with brine, dried (Na2SO4) and concentrated. The residue was purified by silica gel chromatography (15% EtOAc/Hexane) to provide 0.5 g (35%) of white solid.

Источник