Реакция #1106

Уравнение реакции

4-chloro-3-methoxy-2-methylpyridine

4-tert-butylaniline

NaOH

→

4-(4-tert-Butylanilino)-3-methoxy-2-methylpyridine

Растворители

phenol

Условия реакции

Обработка

1. 1
   ТемператураAfter cooling
2. 2
   Экстракцияthe product is extracted
3. 3
   КонцентрированиеAfter concentrating
4. 4
   workup.DISTILLATIONthe excess of amine is distilled off in vacuo
5. 5
   Другоеthe residue is crystallized

Методика

7.9 g of 4-chloro-3-methoxy-2-methylpyridine and 22.4 g of 4-tert-butylaniline are heated at 120° C. for 8 hours in 20 g of phenol. After cooling, the mixture is poured into NaOH and the product is extracted using methylene chloride. After concentrating, the excess of amine is distilled off in vacuo and the residue is crystallized using hexane. 9.5 g=55%

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