Реакция #1095847

Уравнение реакции

3-{Ethoxycarbonylmethyl-[6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoyl]-amino}-propionic acid ethyl ester

→

3-[(6-Amino-hexanoyl)-ethoxycarbonylmethyl-amino]-propionic acid ethyl ester

Растворители

piperidine

dimethylformamide

Условия реакции

Обработка

1. 1
   КонцентрированиеThe reaction mixture was concentrated under vacuum, water
2. 2
   workup.ADDITIONwas added to the residue
3. 3
   Экстракцияthe product was extracted with ethyl acetate
4. 4
   ДругоеThe crude product was purified by conversion into its hydrochloride salt

Методика

3-{Ethoxycarbonylmethyl-[6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoyl]-amino}-propionic acid ethyl ester AB (11.5 g, 21.3 mmol) was dissolved in 20% piperidine in dimethylformamide at 0° C. The solution was continued stifling for 1 h. The reaction mixture was concentrated under vacuum, water was added to the residue, and the product was extracted with ethyl acetate. The crude product was purified by conversion into its hydrochloride salt.

Источник