Реакция #1095846

Уравнение реакции

ethyl acrylate

ethyl glycinate hydrochloride

sodium hydroxide

→

Diethyl-2-azabutane-1,4-dicarboxylate

Растворители

water

Условия реакции

Обработка

1. 1
   ДругоеAfter 19 h the solution was partitioned with dichloromethane (3×100 mL)
2. 2
   СушкаThe organic layer was dried with anhydrous sodium sulfate
3. 3
   Фильтрацияfiltered
4. 4
   Другоеevaporated
5. 5
   workup.DISTILLATIONThe residue was distilled
6. 6
   Другоеto afford AA (28.8 g, 61%)

Методика

A 4.7 M aqueous solution of sodium hydroxide (50 mL) was added into a stirred, ice-cooled solution of ethyl glycinate hydrochloride (32.19 g, 0.23 mole) in water (50 mL). Then, ethyl acrylate (23.1 g, 0.23 mole) was added and the mixture was stirred at room temperature until completion of the reaction was ascertained by TLC. After 19 h the solution was partitioned with dichloromethane (3×100 mL). The organic layer was dried with anhydrous sodium sulfate, filtered and evaporated. The residue was distilled to afford AA (28.8 g, 61%).

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