Реакция #1093

Уравнение реакции

N-tert-butyl-2-methoxycarbonyl-5-nitrobenzenesulfonamide

hydrogen

→

N-tert-Butyl-5-amino-2-methoxycarbonylbenzenesulfonamide

Растворители

MeOH

Условия реакции

Обработка

1. 1
   ДругоеThe catalyst is separated off
2. 2
   Другоеthe solvent is removed by distillation
3. 3
   Другоеto crystallize

Методика

25.08 g (0.079 mol) of N-tert-butyl-2-methoxycarbonyl-5-nitrobenzenesulfonamide are dissolved in 1000 ml of MeOH. 0.50 g of Pd--C (10%) is added and the mixture is shaken under a hydrogen atmosphere (1 atm) until the uptake of hydrogen has finished. The catalyst is separated off and the solvent is removed by distillation. The residue is induced to crystallize by stirring with a little ethyl acetate. The resulting N-tert-butyl-5-amino-2-methoxycarbonylbenzenesulfonamide (18.3 g; 80.9% of theory) melts at 193° C.

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