Реакция #1090905

Уравнение реакции

phenylglyoxal

N-benzylethanolamine

→

N-benzyl-2-benzoyloxazolidine

Выход 90.0%

Условия реакции

Методика

Agami et al, Tetrahedron Lett., (1993) 34, 7061 describes the reaction of phenylglyoxal with (R)-N-methylphenylglycinol in refluxing acetonitrile to give (5R)-3,5-diphenyl-4-methyl-1,4-oxazin-2-one. Under the same conditions, however, we have found that the reaction of phenylglyoxal with N-benzylethanolamine gives predominantly (>90%) N-benzyl-2-benzoyloxazolidine. The desired product, N-benzyl-3-phenyl-1,4-oxazin-2-one was formed at a low level (5%).

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