Реакция #10864

Уравнение реакции

2-(2,6-dichloro-4-trifluoromethylphenylhydrazino)succinonitrile

→

5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole

Растворители

chlorobenzene

Условия реакции

Обработка

1. 1
   ФильтрацияAfter filtration and evaporation

Методика

A mixture of 2-(2,6-dichloro-4-trifluoromethylphenylhydrazino)succinonitrile (0.323 g) and cupric chloride (0.175 g) was heated in chlorobenzene at 60° C. for 6 hours. After filtration and evaporation, the title compound and 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole were obtained as a 7:1 mixture. Column chromatography on silica gel eluting with dichloromethane gave the pure title compound, obtained as a mixture of syn and anti isomers, NMR (anti isomer) 3.6 (s, 2H), 7.57 (s, 2H), 8.82 (s, 1H, exchangeable with D2O), NMR (syn isomer) 3.56 (s, 2H), 7.59 (s, 2H), 8.27 (s, 1H, exchangeable with D2O).

Источник