Реакция #1074524

Уравнение реакции

12-bromododecan-1-ol

12-Bromododecan-1-ol

4-hydroxy-benzaldehyde

potassium carbonate

potassium iodide

→

4-(12-Hydroxy-dodecyloxy)-benzaldehyde

Растворители

methyl ethyl ketone

Условия реакции

Обработка

1. 1
   Температураwas heated
2. 2
   ТемператураAfter cooling
3. 3
   Фильтрацияthe solids were filtered off
4. 4
   Промывкаwashed with acetone
5. 5
   ДругоеThe combined organic fractions were evaporated to dryness
6. 6
   workup.ADDITIONDiethyl ether was added to the resultant oil
7. 7
   Другоеwas stored at 4° C
8. 8
   ДругоеThe title compound precipitated
9. 9
   Фильтрацияwas collected by filtration

Методика

A mixture of 12-bromododecan-1-ol (15 g, 57 mmol, see Example 1 above), 4-hydroxy-benzaldehyde (6.9 g, 57 mmol), potassium carbonate (excess), potassium iodide (trace) and tetra-n-butylammonium iodide (trace) was heated at reflux in methyl ethyl ketone (50 ml) for 16 hours. After cooling, the solids were filtered off and washed with acetone. The combined organic fractions were evaporated to dryness. Diethyl ether was added to the resultant oil and the solution was stored at 4° C. The title compound precipitated and was collected by filtration.

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