Реакция #10700

Уравнение реакции

maleimide

HCOH

NaOH

→

hydroxymethylmaleimide

Условия реакции

Обработка

1. 1
   Другоеreacted at 40° C. for 2 hours
2. 2
   ДругоеAs a result, a white crystal of hydroxymethylmaleimide precipitates
3. 3
   ФильтрацияThis white crystal is filtered under reduced pressure
4. 4
   Другоеdried at normal temperature under vacuum

Методика

24 Parts of maleimide (manufactured by Aldrich Corporation), 21 parts of 35% HCOH (manufactured by Wako Pure Chemical Industries, Ltd.) and 0.7 parts of a 5% aqueous NaOH solution are placed in a reactor and reacted at 40° C. for 2 hours. As a result, a white crystal of hydroxymethylmaleimide precipitates. This white crystal is filtered under reduced pressure and then dried at normal temperature under vacuum. The crude crystal of hydroxymethylmaleimide obtained in this manner is recrystallized from ethyl acetate to obtain 22 parts of hydroxymethylmaleimide.

Источник