Реакция #10678

Уравнение реакции

Intermediate 133

4-(1-amino-5-isoquinolyl)amino-1-(tert-butoxycarbonyl)piperidine

hydrogen chloride methanol

→

title compound

Выход 71.7%

4-(1-amino-5-isoquinolyl)aminopiperidine

Выход 71.7%

Условия реакции

Обработка

1. 1
   Другое(room temperature, 2 hours)
2. 2
   ДругоеThe solvent was evaporated under reduced pressure
3. 3
   workup.ADDITIONthe residue was added with methanol (1 ml) and diethyl ether (3 ml)
4. 4
   ДругоеThe deposited precipitates
5. 5
   Фильтрацияwere collected by filtration
6. 6
   Промывкаwashed with diethyl ether

Методика

According to the method of Example 1, Step C, deprotection was performed (room temperature, 2 hours) by using Intermediate 133 (199 mg) and 10% hydrogen chloride/methanol solution (3 ml). The solvent was evaporated under reduced pressure, and the residue was added with methanol (1 ml) and diethyl ether (3 ml). The deposited precipitates were collected by filtration and washed with diethyl ether to obtain the title compound (101 mg).

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