Реакция #1062217

Уравнение реакции

sodium hydrogen carbonate

4-Methyl-5-oxazolecarbonyl chloride

N,O-dimethylhydroxylamine hydrochloride

pyridine

→

title compound

N-Methoxy-N-methyl-4-methyl-5-oxazolecarboxamide

Растворители

chloroform

Условия реакции

Обработка

1. 1
   Другоеthe organic layer separated
2. 2
   ЭкстракцияThe aqueous layer was extracted with dichloromethane
3. 3
   ПромывкаThe combined organic layers were washed
4. 4
   Другоеdried
5. 5
   Другоеevaporated
6. 6
   ДругоеThe residue was purified by flash chromatography

Методика

4-Methyl-5-oxazolecarbonyl chloride (15 g) and N,O-dimethylhydroxylamine hydrochloride (11 g) in dry chloroform (100 ml) were cooled to 0° C. and dry pyridine (28.5 g) was added. The mixture was allowed to warm to room temperature. After 30 minutes aqueous sodium hydrogen carbonate was added and the organic layer separated. The aqueous layer was extracted with dichloromethane. The combined organic layers were washed, dried and evaporated. The residue was purified by flash chromatography to yield the title compound as a white solid. M.p. 59°-60° C.

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