Реакция #1058977

Уравнение реакции

1-(3-chloropropyl)-1H-benzimidazole

4-(4-chlorophenyl)-4-piperidinol

sodium carbonate

potassium iodide

→

1-[3-(1H-benzimidazol-1-yl)propyl]-4-(4-chlorophenyl)-4-piperidinol

Выход 67.6%

Растворители

4-methyl-2-pentanone

water

water

Условия реакции

Обработка

1. 1
   ТемператураThe reaction mixture is cooled
2. 2
   Другоеthe layers are separated
3. 3
   ДругоеThe organic phase is dried
4. 4
   Фильтрацияfiltered
5. 5
   Другоеevaporated
6. 6
   ДругоеThe residue is crystallized from 4-methyl-2-pentanone
7. 7
   ФильтрацияThe product is filtered off
8. 8
   Другоеdried

Методика

A mixture of 4.86 parts of 1-(3-chloropropyl)-1H-benzimidazole, 4.24 parts of 4-(4-chlorophenyl)-4-piperidinol, 5.3 parts of sodium carbonate, 0.1 parts of potassium iodide and 200 parts of 4-methyl-2-pentanone is stirred and refluxed for 20 hours with water-separator. The reaction mixture is cooled, water is added and the layers are separated. The organic phase is dried, filtered and evaporated. The residue is crystallized from 4-methyl-2-pentanone. The product is filtered off and dried, yielding 5 parts (67.6%) of 1-[3-(1H-benzimidazol-1-yl)propyl]-4-(4-chlorophenyl)-4-piperidinol; mp. 160° C.

Источник