Реакция #1052426

Уравнение реакции

1,2-dichloro-4-fluorobenzene

(±) cis 2-methylamino-1-indanol

sodium hydride

→

title compound

(±) cis 1-(3,4-Dichlorophenoxy)-2-methylaminoindane Hydrochloride

Условия реакции

Обработка

1. 1
   ДругоеThe crude product was purified by chromatography on silica eluting with 0-3% ethanol in diethyl ether
2. 2
   workup.DISSOLUTIONThe resulting brown oil (1.3 g) was dissolved in hexane
3. 3
   workup.ADDITIONtreated with ethereal HCl

Методика

The title compound was prepared in a similar manner to Example 26 from (±) cis 2-methylamino-1-indanol (0.815 g, 5.0 mmol), sodium hydride (0.18 g of an 80% dispersion in oil; 6.0 mmol) and 1,2-dichloro-4-fluorobenzene (0.99 g, 6.0 mmol). The crude product was purified by chromatography on silica eluting with 0-3% ethanol in diethyl ether. The resulting brown oil (1.3 g) was dissolved in hexane and treated with ethereal HCl to give the hydrochloride salt. Recrystallisation afforded the title compound as a colourless solid, m.p. 238°-239° C. (dec) (from methanoildiethyl ether).

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