Реакция #1052424

Уравнение реакции

1,2-dichloro-4-fluorobenzene

(±) cis 2-amino-1-indanol

sodium hydride

→

title compound

(±) cis 2-Amino-1-(3,4dichlorophenoxy)indane Hydrochloride

Условия реакции

Обработка

1. 1
   ДругоеThe crude product was purified by chromatography on silica eluting with 0-4% ethanol in diethyl ether
2. 2
   ЭкстракцияThe resulting light brown oil (3.89 g) was extracted into a mixture of hexane and diethyl ether
3. 3
   workup.ADDITIONtreated with ethereal HCl

Методика

The title compound was prepared in a similar manner to Example 26 from (±) cis 2-amino-1-indanol (2.24 g, 15.0 mmol), sodium hydride (0.54 g of an 80% dispersion in oil; 18.0 mmol) and 1,2-dichloro-4-fluorobenzene (2.97 g, 18.0 mmol). The crude product was purified by chromatography on silica eluting with 0-4% ethanol in diethyl ether. The resulting light brown oil (3.89 g) was extracted into a mixture of hexane and diethyl ether and treated with ethereal HCl to give the hydrochloride salt. Recrystallisation afforded the title compound as a colourless solid, m.p. 214°-215° C. (dec) (from methanol/ethyl acetate/diethyl ether).

Источник