Реакция #1045

Уравнение реакции

2,3,3-trifluoro-2-propenyl bromide

triethyl phosphite

→

diethyl (1,1,2-trifluro-2-propenyl)phosphonate

Выход 11.0%

diethyl (2,3,3-trifluro-2-propenyl)phosphonate

Выход 14.0%

Условия реакции

Обработка

1. 1
   Температураat reflux for overnight
2. 2
   ДругоеThe residue obtained
3. 3
   Другоеafter evaporation of the solvent
4. 4
   Другоеwas chromatographed over silica gel (hexanes/ethyl acetate/ethanol, 80/20/1)

Методика

A solution of 2,3,3-trifluoro-2-propenyl bromide (5.25 g, 30 mmol) and triethyl phosphite (4.15 g, 25 mmol) in acetonltrile (15 mL) was heated at reflux for overnight. The residue obtained after evaporation of the solvent was chromatographed over silica gel (hexanes/ethyl acetate/ethanol, 80/20/1) to give diethyl (1,1,2-trifluro-2-propenyl)phosphonate (0.8 g, 11%) and diethyl (2,3,3-trifluro-2-propenyl)phosphonate (1.0 g, 14%).

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