Реакция #1044

Уравнение реакции

1,2,4-triazole

3,4,4-trifluoro-3-butenoyl chloride

→

desired product

Выход 94.2%

1-(3,4,4-trifluoro-1-oxo-3-butenyl)-1H-1,2,4-triazole

Выход 94.2%

Растворители

ethyl acetate

Условия реакции

Обработка

1. 1
   workup.STIRRINGThe mixture was stirred for 30 min
2. 2
   Фильтрацияfiltered
3. 3
   ДругоеThe residue obtained
4. 4
   Другоеafter evaporation of the solvent
5. 5
   workup.DISSOLUTIONwas redissolved in dichloromethane (25 mL)
6. 6
   Фильтрацияfiltered
7. 7
   ДругоеEvaporation of the solvent

Методика

To a solution of 1,2,4-triazole (1.38 g, 20 mmol) in ethyl acetate (100 mL) was added 3,4,4-trifluoro-3-butenoyl chloride (1.59 g, 10 mmol) at r.t. with stirring. The mixture was stirred for 30 min and filtered. The residue obtained after evaporation of the solvent was redissolved in dichloromethane (25 mL) and filtered. Evaporation of the solvent gave 1.8 g (94%) of the desired product as a dear oil.

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