Реакция #10438

Уравнение реакции

2-chloro-5-fluoro-6-methylsulfanylnicotinic acid ethyl ester

cyclopropylamine

cyclopropylamine

→

title compound

Выход 69.1%

2-cyclopropylamino-5-fluoro-6-methylsulfanylnicotinic acid ethyl ester

Выход 69.1%

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   Температураat reflux for 18 hours
2. 2
   workup.ADDITIONis added
3. 3
   Температураthe reaction mixture is refluxed for 48 hours
4. 4
   ДругоеThe solvent is removed in vacuo
5. 5
   Другоеthe residue is partitioned between dichloromethane (250 mL) and water (100 mL)
6. 6
   ПромывкаThe organic layer is washed with water
7. 7
   Сушкаdried (MgSO4)
8. 8
   Фильтрацияfiltered
9. 9
   Концентрированиеconcentrated in vacuo
10. 10
    ДругоеThe residue is chromatographed over flash grade silica gel (230–400 mesh)
11. 11
    Промывкаeluting with dichloromethane

Методика

A solution of 8.7 g (34.8 mmol) of 2-chloro-5-fluoro-6-methylsulfanylnicotinic acid ethyl ester (J. Med. Chem., 1993; 36:2676) and 5.7 g (100 mmol) of cyclopropylamine in 100 mL of acetonitrile is heated at reflux for 18 hours. After TLC showed the presence of unreacted starting material, 4.12 g (72 mmol) of cyclopropylamine is added and the reaction mixture is refluxed for 48 hours. The solvent is removed in vacuo and the residue is partitioned between dichloromethane (250 mL) and water (100 mL). The organic layer is washed with water, dried (MgSO4), filtered, and concentrated in vacuo. The residue is chromatographed over flash grade silica gel (230–400 mesh) eluting with dichloromethane to give 6.5 g of the title compound, mp 67–69° C.

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