Реакция #10316

Уравнение реакции

alcohol

1-(2,4-difluorophenyl)-2-(3-{[(4-fluorophenyl)sulfonyl]methyl}azetidin-1-yl)ethanol

(Diethylamino)sulfur trifluoride

→

title compound

Выход 50.1%

1-[2-(2,4-Difluorophenyl)-2-fluoroethyl]-3-{[(4-fluorophenyl)sulfonyl]methyl}azetidine

Выход 50.1%

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas added dropwise and after 30 minutes the cooling bath
2. 2
   Другоеwas removed
3. 3
   Другоеthe reaction was quenched with saturated aqueous sodium hydrogencarbonate solution
4. 4
   Экстракцияextracted with dichloromethane
5. 5
   ПромывкаThe combined organic layers were washed with water and brine
6. 6
   Сушкаdried over MgSO4
7. 7
   Другоеevaporated in vacuo
8. 8
   ДругоеThe residue was purified by preparative TLC (50% ethyl acetate/isohexane)

Методика

A stirred suspension of the alcohol from Step 1 (130 mg, 0.33 mmol) in dichloromethane (4 mL) under nitrogen was cooled to −10° C. (Diethylamino)sulfur trifluoride (54 μL, 0.41 mmol) was added dropwise and after 30 minutes the cooling bath was removed. After a further 15 minutes, the reaction was quenched with saturated aqueous sodium hydrogencarbonate solution and extracted with dichloromethane. The combined organic layers were washed with water and brine, dried over MgSO4 and evaporated in vacuo. The residue was purified by preparative TLC (50% ethyl acetate/isohexane) to give the title compound (64 mg, 50%). 1H NMR (500 MHz, CDCl3) δ 7.91–7.89 (2H, m), 7.40–7.34 (1H, m), 7.27–7.23 (2H, m), 6.90 (1H, t, J=8.2 Hz), 6.79 (1H, t, J=9.5 Hz), 5.70–5.58 (1H, m), 3.49 (2H, q, J=7.4 Hz), 3.38–3.36 (2H, m), 2.95 (2H, q, J=6.7 Hz), 2.90–2.70 (3H, m); m/z (ES+) 388 (M+H)+.

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