Реакция #10249

Уравнение реакции

2-chloro-1,2,3,4-tetrahydro-3-phenylsulfonyl-1,4-ethanonaphthalene

1,8-diazabicyclo[5.4.0]-7-undecene

hydrochloric acid

→

1,4-dihydro-2-phenylsulfony-1,4-ethanonaphthalene

Выход 98.0%

Растворители

THF

Условия реакции

Обработка

1. 1
   Экстракцияextracted with chloroform
2. 2
   Промывкаwashed with distilled water
3. 3
   Сушкаan aqueous saturated sodium bicarbonate solution and saturated saline and dried with anhydrous sodium sulfate
4. 4
   ДругоеThe product was purified with silica gel column chromatography (chloroform)

Методика

A solution of 0.3 g (0.91 mmol) of the obtained 2-chloro-1,2,3,4-tetrahydro-3-phenylsulfonyl-1,4-ethanonaphthalene and 15 ml of anhydrous THF was cooled to 0° C., added with 2.5 ml of 1,8-diazabicyclo[5.4.0]-7-undecene and stirred for 30 minutes. The solution is then added with a dilute hydrochloric acid solution, extracted with chloroform, washed with distilled water, an aqueous saturated sodium bicarbonate solution and saturated saline and dried with anhydrous sodium sulfate. The product was purified with silica gel column chromatography (chloroform) to obtain 1,4-dihydro-2-phenylsulfony-1,4-ethanonaphthalene (0.264 g, 0.89 mmol, yield: 98%).

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