Реакция #1005985

Уравнение реакции

2-chloromethylquinoline hydrochloride

potassium carbonate

tert-butyl piperazine-1-carboxylate

→

2-(piperazin-1-ylmethyl)quinoline

Выход 92.0%

Растворители

acetone

Условия реакции

Обработка

1. 1
   ДругоеReaction
2. 2
   Фильтрацияfiltered through celite
3. 3
   КонцентрированиеFiltrate was concentrated on Rotavapor under vacuum
4. 4
   Другоеthe crude residue was purified on SiO2 using Biotage SP1

Методика

To a solution of 2-chloromethylquinoline hydrochloride (5 mmol) in anhydrous acetone (100 mL) was added, anhydrous potassium carbonate (15 mmol) and tert-butyl piperazine-1-carboxylate (7 mmol) and the reaction mixture was stirred under reflux conditions for 12 h. Reaction was cooled to r.t. and filtered through celite. Filtrate was concentrated on Rotavapor under vacuum and the crude residue was purified on SiO2 using Biotage SP1 to give a pure 2-(piperazin-1-ylmethyl)quinoline (6.3, 92%, pale yellow solid).

Источник