Реакция #1005957

Уравнение реакции

5-Bromoindan-1-one

Hydroxylammonium chloride

sodium acetate

→

5-bromo-N-hydroxyindan-1-imine

Выход 95.2%

Растворители

methanol

water

Условия реакции

Обработка

1. 1
   Экстракцияextracted twice with ethyl acetate
2. 2
   Промывкаwashed with water
3. 3
   Сушкаdried over anhydrous magnesium sulfate
4. 4
   ФильтрацияThe desiccant was filtered
5. 5
   Другоеseparated
6. 6
   Другоеthe solvent was evaporated off under reduced pressure

Методика

5-Bromoindan-1-one (5.0 g) was dissolved in methanol. Hydroxylammonium chloride (2.5 g) and sodium acetate (2.9 g) were added to the solution at room temperature, and then stirred overnight. The reaction solution was diluted with water and extracted twice with ethyl acetate. The organic layers were combined, washed with water, and dried over anhydrous magnesium sulfate. The desiccant was filtered and separated, and then the solvent was evaporated off under reduced pressure to obtain 5-bromo-N-hydroxyindan-1-imine (5.1 g).

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