Реакция #1005944

Уравнение реакции

3-(3,5-Dichlorophenyl)-3-(trifluoromethyl)pyrrolidine

4-fluoro-2-trifluoromethylbenzonitrile

potassium carbonate

N,N-dimethylformamide

→

title compound

Выход 42.5%

4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-(trifluoromethyl)-benzonitrile

Выход 42.5%

Растворители

ethyl acetate

Условия реакции

Обработка

1. 1
   ТемператураAfter cooling the mixture to room temperature
2. 2
   Промывкаwashed with water three times
3. 3
   СушкаThe organic layer was dried over anhydrous magnesium sulfate
4. 4
   ДругоеThe solvent was evaporated off under reduced pressure
5. 5
   Другоеthe residue was then purified by a column chromatography

Методика

3-(3,5-Dichlorophenyl)-3-(trifluoromethyl)pyrrolidine (5.6 g), 4-fluoro-2-trifluoromethylbenzonitrile (4.5 g) and potassium carbonate (5.4 g) were added to N,N-dimethylformamide (50 mL), and the mixture was stirred at 110° C. for 4 hours. After cooling the mixture to room temperature, the solution was diluted with ethyl acetate and washed with water three times. The organic layer was dried over anhydrous magnesium sulfate. The solvent was evaporated off under reduced pressure, and the residue was then purified by a column chromatography to obtain the title compound (3.8 g).

Источник