Реакция #10047

Уравнение реакции

Triethylamine

methyl-3-(aminomethyl)-2-(methoxycarbonyl)benzoate hydrochloride

Acetyl chloride

→

product

Выход 80.0%

3-(Acetylamino-methyl)-phthalic acid dimethyl ester

Выход 80.0%

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   Другоеstayed between 4–7° C
2. 2
   workup.ADDITIONAfter addition
3. 3
   Температураto warm to room temperature
4. 4
   Температураmaintained for 2 hours
5. 5
   ПромывкаThe reaction mixture was washed with water (2×30 ml), brine (30 ml)
6. 6
   Другоеdried
7. 7
   ДругоеSolvent was removed in vacuo
8. 8
   Другоеthe product was purified by chromatography (dichloromethane/ethyl acetate 6 to 4)

Методика

Triethylamine (1.87 g, 18 mmol) was added slowly to a stirred suspension of methyl-3-(aminomethyl)-2-(methoxycarbonyl)benzoate hydrochloride (2.0 g, 8 mmol) in dichloromethane (30 ml). The resulting mixture was cooled in an ice bath to 4° C. Acetyl chloride (0.73 g, 9 mmol) was added dropwise at a rate such that the temperature stayed between 4–7° C. After addition was complete, the mixture was stirred in the ice bath for an additional 30 minutes and then allowed to warm to room temperature and maintained for 2 hours. The reaction mixture was washed with water (2×30 ml), brine (30 ml) and dried. Solvent was removed in vacuo and the product was purified by chromatography (dichloromethane/ethyl acetate 6 to 4) to afford 1.65 g (80%) of the product as an oil: 1H NMR (CDCl3) δ 7.86 (d, J=7.7 Hz, 1H), 7.62 (d, J=7.6 Hz); 7.46 (t, J=7.7 Hz); 6.29 (b, 1H), 4.39 (d, J=6.1 Hz, 2H), 3.93 (s, 3H), 3.90 (s, 3H), 1.96 (s, 3H).

Источник