Реакция #10036

Уравнение реакции

(2S,4R)-trans-4-hydroxyproline

formamide

hydrogen

→

title compound

Выход 92.1%

(2S, 4R)-4-hydroxy-1-methyl-2-pyrrolidinecarboxylic acid

Выход 92.1%

Растворители

ethanol

water

Условия реакции

Обработка

1. 1
   ДругоеAfter removing the palladium on charcoal
2. 2
   Фильтрацияby filtration
3. 3
   Другоеthe water of the filtrate was removed by distillation under reduced pressure
4. 4
   ДругоеThe solid residue thus obtained
5. 5
   ДругоеThe crystals which precipitated
6. 6
   Фильтрацияwere collected by filtration

Методика

A suspension of (2S,4R)-trans-4-hydroxyproline (5 g), 37% aqueous formamide solution (4.6 g) and 7.5% palladium on charcoal (53% water content, 3.2 g) in water (15 mL) was stirred at room temperature in an atmosphere of high-pressure hydrogen for 10 hours. After removing the palladium on charcoal by filtration, the water of the filtrate was removed by distillation under reduced pressure. The solid residue thus obtained was suspended and stirred in ethanol (25 mL). The crystals which precipitated were collected by filtration to give the title compound (5.1 g, yield 92%).

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