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79931

Cc1ccccc1-c1cc(N2CCN(C)CC2)ncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1
Reaction #181249
DOI: 10.1039/C8SC04228D
CC(=O)N1CCN(c2cc(-c3ccccc3C)c3c(n2)OCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)CC1
Reaction #243634
DOI: 10.1039/C8SC04228D
Cc1ccccc1-c1cc(N2CCN(C=O)CC2)ncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1
Reaction #285349
DOI: 10.1039/C8SC04228D
Cc1ccccc1-c1cc(N2CCN(CCOCCO)CC2)ncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1
Reaction #368630
DOI: 10.1039/C8SC04228D
Cc1ccccc1-c1cc(N2CCN(CCO)CC2)ncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1
Reaction #376044
DOI: 10.1039/C8SC04228D
CC(=O)N1CCN(c2cc(-c3ccccc3C)c3c(n2)OCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)CC1
Reaction #378969
DOI: 10.1039/C8SC04228D
Cc1ccccc1-c1cc(N2CCN(C)CC2)ncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1
Reaction #404059
DOI: 10.1039/C8SC04228D
Cc1ccccc1-c1cc(N2CCN(C(=O)OC(C)(C)C)CC2)ncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1
Reaction #439503
parent compound
Выход 70.8%DOI: 10.6084/m9.figshare.5104873.v1
Cc1ccccc1-c1cc(N2CCN(C)CC2)ncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1
Reaction #466553
N-(3,5-bis-trifluoromethyl-benzyl)-N-methyl-6-(4-methyl-piperazin-1-yl)-4-o-tolyl-nicotinamide
Выход 75.0%DOI: 10.6084/m9.figshare.5104873.v1
Cc1ccccc1-c1cc(N2CCNCC2)ncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1
Reaction #466577
title compound
Выход 87.4%DOI: 10.6084/m9.figshare.5104873.v1
Cc1ccccc1-c1cc(N2CCN(CCO)CC2)ncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1
Reaction #466578
title compound
Выход 78.7%DOI: 10.6084/m9.figshare.5104873.v1
Cc1ccccc1-c1cc(N2CCN(CCOCCO)CC2)ncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1
Reaction #466579
title compound
Выход 64.4%DOI: 10.6084/m9.figshare.5104873.v1
Cc1ccccc1-c1cc(N2CCN(C=O)CC2)ncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1
Reaction #466580
title compound
Выход 82.0%DOI: 10.6084/m9.figshare.5104873.v1
Cc1ccccc1-c1cc(N2CCN(Cc3nnn[nH]3)CC2)ncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1
Reaction #466582
title compound
Выход 90.3%DOI: 10.6084/m9.figshare.5104873.v1
Cc1ccccc1-c1cc(N2CCN(C)CC2)ncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1
Reaction #466595
product
Выход 84.9%DOI: 10.6084/m9.figshare.5104873.v1
Cc1ccccc1-c1cc(N2CCN(C)CC2)ncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1
Reaction #467931
product
Выход 84.9%DOI: 10.6084/m9.figshare.5104873.v1
Cc1ccccc1-c1cc(N2CCN(C(=O)OC(C)(C)C)CC2)ncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1
Reaction #480558
parent compound
Выход 70.8%DOI: 10.6084/m9.figshare.5104873.v1
Cc1ccccc1-c1cc(N2CCN(C)CC2)ncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1
Reaction #1104613
N-(3,5-bis-trifluoromethyl-benzyl)-N-methyl-6-(4-methyl-piperazin-1-yl)-4-o-tolyl-nicotinamide
Выход 75.0%DOI: 10.6084/m9.figshare.5104873.v1
Cc1ccccc1-c1cc(N2CCNCC2)ncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1
Reaction #1104640
title compound
Выход 87.4%DOI: 10.6084/m9.figshare.5104873.v1
Cc1ccccc1-c1cc(N2CCN(CCO)CC2)ncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1
Reaction #1104641
title compound
Выход 78.7%DOI: 10.6084/m9.figshare.5104873.v1
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