반응 #9996

반응 방정식

2-chloro-9-ethyl-6-(3-trifluoromethyl-phenyl-amino)-9H-purine

3-amino-1-propanol

→

9-Ethyl-2-(3-hydroxy-propyl-amino)-6-(3-trifluoromethyl-phenyl-amino)-9H-purine

용매

ethyl acetate

반응 조건

후처리

1. 1
   온도to cool
2. 2
   세척The organic phase is washed with water
3. 3
   건조dried over sodium sulfate
4. 4
   기타After removal of the solvent
5. 5
   기타the residue is recrystallized from ethyl acetate and diethyl ether

실험 절차

200 mg (0.58 mmol) of 2-chloro-9-ethyl-6-(3-trifluoromethyl-phenyl-amino)-9H-purine and 2 ml of 3-amino-1-propanol are stirred at 140° C. for 2 h and the mixture is allowed to cool and is diluted with 60 ml of ethyl acetate. The organic phase is washed with water and dried over sodium sulfate. After removal of the solvent, the residue is recrystallized from ethyl acetate and diethyl ether. 9-Ethyl-2-(3-hydroxy-propyl-amino)-6-(3-trifluoromethyl-phenyl-amino)-9H-purine is obtained; m.p. 136–137° C.; FAB-MS: (M+H)+=381; Rf=0.7 (ethyl acetate:methanol=9:1).

출처