반응 #999335

반응 방정식

4-methyl-3-nitro-benzoic acid

HOBt

N-ethylpiperazine

→

(4-ethyl-piperazin-1-yl)-(4-methyl-3-nitro-phenyl)-methanone

수율 95.0%

용매

dichloromethane

반응 조건

후처리

1. 1
   세척The reaction mixture was washed with aqueous ammonium chloride solution
2. 2
   건조subsequently dried over sodium sulfate
3. 3
   여과After filtering sodium sulfate
4. 4
   농축the filtrate was concentrated under reduced pressure

실험 절차

To 4-methyl-3-nitro-benzoic acid (730 mg, 4.03 mmol), WSCI (930 mg, 4.85 mmol), HOBt (110 mg, 0.674 mmol) and N-ethylpiperazine (608 μl, 4.79 mmol), dichloromethane (8 ml) was added, followed by stirring for 13 hours. The reaction mixture was washed with aqueous ammonium chloride solution, and subsequently dried over sodium sulfate. After filtering sodium sulfate, the filtrate was concentrated under reduced pressure, to obtain (4-ethyl-piperazin-1-yl)-(4-methyl-3-nitro-phenyl)-methanone (1.06 g, 95%).

출처