반응 #998514

반응 방정식

5-methyl-benzoxazole

NBS

AIBN

→

title compound

수율 13.0%

5-Bromomethyl-benzoxazol

수율 13.0%

용매

chloroform

chloroform

반응 조건

후처리

1. 1
   세척wash with water
2. 2
   건조Dry the organic extracts over anhydrous Na2SO4
3. 3
   기타evaporate the solvent
4. 4
   기타purify by chromatography on silica gel eluting with hexane/EtOAc (1:0, 9:1, 4:1 and 7:3)

실험 절차

Combine 5-methyl-benzoxazole (0.5 g, 3.75 mmol), NBS (0.7 g, 3.93 mmol), AIBN (60 mg, 0.37 mmol), chloroform (10 mL) and reflux for 1 h. Cool the reaction mixture to ambient temperature, dilute with chloroform and wash with water. Dry the organic extracts over anhydrous Na2SO4, evaporate the solvent and purify by chromatography on silica gel eluting with hexane/EtOAc (1:0, 9:1, 4:1 and 7:3) to obtain the title compound as a white solid (0.1 g, 13%).

출처